ABSTRACT
The two clinico-pathological patterns are 'Sweet-like syndrome' and 'Multiple COVID-Arm'. 'Sweet-like syndrome' presents clinically as erythematous and oedematous papules or plaques, sometimes developing vesiculation or bullae. Histology shows classical Sweet syndrome with a diffuse dermal neutrophilic infiltrate, or an infiltrate of histiocyte-like immature myeloid cells consistent with a histiocytoid Sweet syndrome. 'Multiple COVID-arm' is characterized by multiple large inflammatory plaques with histological analyses showing a perivascular and interstitial inflammatory infiltrate with eosinophils.
Subject(s)
COVID-19 , Sweet Syndrome , Arm/pathology , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Histiocytes/pathology , Humans , Sweet Syndrome/diagnosis , Sweet Syndrome/etiology , Sweet Syndrome/pathologySubject(s)
COVID-19 , Sweet Syndrome , Humans , Neutrophils , SARS-CoV-2 , Sweet Syndrome/diagnosis , Sweet Syndrome/etiologyABSTRACT
Vaccination for COVID19 infection is in full swing all around the world and while the vaccines are considered overall safe, many cutaneous and extracutaneous adverse effects have been reported after their use. Local injection-site reactions are the commonest adverse effect described with the use of these vaccines. We describe a case of Sweet syndrome in an elderly female after the first dose of Oxford-AstraZeneca COVID-19 vaccine (AZD1222).
Subject(s)
COVID-19 , Sweet Syndrome , Aged , COVID-19 Vaccines , ChAdOx1 nCoV-19 , Female , Humans , SARS-CoV-2 , Sweet Syndrome/chemically induced , Sweet Syndrome/diagnosisABSTRACT
A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.